New published data

HUB Organoids™ advance treatment for Cystic Fibrosis

Promoting full-length CFTR protein production is a requisite step to address some of the remaining unmet medical need for Cystic Fibrosis (CF) patients carrying the nonsense allele G542X

Read this paper to discover:

  • How ELX-02 treatment (Eloxx Pharmaceuticals, Inc.) can restore CFTR protein expression in patient-derived organoids
  • How data obtained using HUB Organoids™ further supports the on-going clinical evaluation of ELX-02 as a read-through agent for CF caused by the G542X allele.

Discover more from HUB

forskolin swelling assay

FIS assay

Quantify Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein activity for the evaluation of new treatment strategies.

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red and green fluorescence

Drug screening services

HUB Organoids preserve disease-specific mutations and can be used in drug screens to predict patient response in the clinic.

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cystic fibrosis

Discover our CF biobank

More than 700 organoid models from rectal biopsies of CF patients and representing more than 100 clinically-relevant mutations.

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