---
title: 10 years of breathroughs in organoid technology
description: Embark on a journey through an extraordinary decade of advancements in patient-derived organoid technology. Follow the discovery of lgr5+ stem cell markers to the refinement of organoid cultivation techniques for disease modeling and drug development
image: https://resources.huborganoids.nl/hubfs/HUB_10YEARS_TEASER1_v4%20copy-1.png
---

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#### CELEBRATING

# ![](https://resources.huborganoids.nl/hs-fs/hubfs/assets2023/10-year-logo.png?width=150&name=10-year-logo.png)10 Years of Breakthroughs in Organoid Technology 

Over the past 10 years, we've decoded the dynamics of adult stem cells, optimized organoid culture conditions, established a vast biobank of patient-derived organoids spanning various diseases and tissue types, and introduced groundbreaking readouts and assays revealing the complex interactions between tumors and the immune system.

In honor of the extraordinary breakthroughs that have played a pivotal role in closing the gap between the lab and the clinic, we extend a warm invitation to partake in our festivities commemorating this revolutionary decade. 

Join us in the celebrations now!

## An impressive array of scientific insights

#### ON DEMAND WEBINAR

### 10 years of breakthroughs in Organoid Technology: from adult stem cell discovery to changing patients’ lives

6th September 2023 | ONLINE

[watch now](https://resources.huborganoids.nl/10-years-of-breakthroughs-in-organoid-technology)

#### PANEL DISCUSSION

### Conversation with the pioneers: unveiling breakthroughs in Organoid Technology

28th September 2023 | ONLINE

[watch now](https://resources.huborganoids.nl/10-year-anniversary-panel-discussion)

#### EXCLUSIVE INTERVIEW 

### Conversation with our CEO: A 10-year journey of advancements in Organoid Technology

[watch now](https://resources.huborganoids.nl/conversation-with-our-ceo)

## Explore our journey so far

![](https://www.huborganoids.nl/wp-content/uploads/2023/08/timeline-2009.png)

### 2009

First organoid generated from mouse intestine

![](https://www.huborganoids.nl/wp-content/uploads/2023/08/story-item-logo3.png)

### 2011

First human organoid developed from intestinal epithelium

![](https://www.huborganoids.nl/wp-content/uploads/2023/08/story-item-logo4.png)

### 2013

Hubrecht Organoid Technology Foundation was established to upscale and commercialize organoid technology

![](https://www.huborganoids.nl/wp-content/uploads/2023/08/timeline-5.png)

### 2015

First cystic fibrosis patient treated based on organoid data

![](https://www.huborganoids.nl/wp-content/uploads/2023/08/timeline-6.png)

### 2017

HIT-CF validation trial launched

![](https://www.huborganoids.nl/wp-content/uploads/2023/08/timeline-7.png)

### 2018

First oncology clinical candidate entirely developed using organoid screening approved for clinical trials

![](https://www.huborganoids.nl/wp-content/uploads/2023/08/timeline-8.png)

### 2022

Expansion of lab facilities

![](https://www.huborganoids.nl/wp-content/uploads/2023/08/timeline-9.png)

### 2023

Hubrecht Organoid Technology becomes HUB Organoids B.V.

## Dive deeper into organoid technology

#### ORGANOID TECHNOLOGY

### Single Lgr5 stem cell build crypt-villus structures in vitro without a mescenchymal niche

Nature | May 2009

[read now](https://resources.huborganoids.nl/publication/single-lgr5-stem-cells-build-crypt-villus-structures-in-vitro-without-a-mesenchymal-niche)

#### ONCOLOGY

### First clinical candidate developed using HUB Organoids in five years 

Case study

[download now](https://resources.huborganoids.nl/case-study-drug-discovery-to-clinical-trials-in-five-years)

#### ORGANOID TECHNOLOGY

### The FDA Modernization Act 2.0: A patient-centric paradigm shift in drug development

Blog

[read more](https://blog.huborganoids.nl/patient-centric-drug-development-with-organoids)

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