New published data

HUB Organoids™ advance treatment for Cystic Fibrosis

Promoting full-length CFTR protein production is a requisite step to address some of the remaining unmet medical need for Cystic Fibrosis (CF) patients carrying the nonsense allele G542X

Read this paper to discover:

  • How ELX-02 treatment (Eloxx Pharmaceuticals, Inc.) can restore CFTR protein expression in patient-derived organoids
  • How data obtained using HUB Organoids™ further supports the on-going clinical evaluation of ELX-02 as a read-through agent for CF caused by the G542X allele.

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FIS assay

Quantify Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein activity for the evaluation of new treatment strategies.

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Drug screening services

HUB Organoids preserve disease-specific mutations and can be used in drug screens to predict patient response in the clinic.

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Discover our CF biobank

More than 700 organoid models from rectal biopsies of CF patients and representing more than 100 clinically-relevant mutations.

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