PRESENTED AT ELRIG 2023
Organoid monolayers: a patient-relevant platform to study intestinal barrier function, inflammatory bowel disease (IBD), and GI toxicity
Conducting comprehensive studies on the intestinal epithelial barrier has been challenging due to the absence of suitable physiologically relevant in vitro systems. Patient-derived organoids (PDOs) have emerged as a promising solution, effectively replicating cellular diversity and patient heterogeneity, providing an insightful platform for exploring the complexities of the intestinal epithelium and its responses to microbial or inflammatory challenges. This poster presents the development of biobanks consisting of patient-derived and animal models-derived organoids, as well as the applications of PDO monolayers in predicting gastrointestinal (GI) toxicity, analyzing drug transport, and advancing research in inflammatory bowel disease (IBD).
Download this poster to discover:
- Insights into our established biobanks of patient-derived and animal-derived organoids for toxicology research
- Key attributes of the PDO Monolayer platform, focusing on gut permeability and transport studies
- The role of PDO Monolayer in predicting gastrointestinal toxicity and facilitating advancements in IBD therapeutics