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Patient-Derived Organoids: A New Frontier in ADC Development

See how PDOs are accelerating ADC development and explore real-world case studies where our insights guided key preclinical development decisions

See why biotech innovators are choosing organoid technology

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Why choose Organoid Technology for your ADC program?

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Traditional ADC models like 2D cell lines and PDXs often fail to predict clinical outcomes, leading to high attrition and dose-limiting toxicities. Patient-derived organoids (PDOs) provide a more predictive alternative. These 3D tumor models preserve patient-specific architecture and genetics, enabling accurate assessment of ADC efficacy and off-target toxicities across both tumor and healthy tissues.

What you'll learn:

  • How patient-derived organoids (PDOs) outperform traditional cell lines and PDX models in ADC development
  • Data showcasing how HUB Organoids capture the diversity of patient responses
  • An overview of our comprehensive ADC services portfolio
  • Two in-depth case studies illustrating how we’ve helped clients make confident, data-driven preclinical decisions

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Discover our ADC development solutions

Whether you need to assess antigen expression in patient-derived models, evaluate ADC potency and off-target toxicities, or run basket screens across multiple cancer indications, our tailored service packages are designed to accelerate your program.

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