---
title: "SOT 2024: HUB Organoids as a Reliable Platform to Assess Gastrointestinal Toxicity"
description: "Download our poster presented at SOT 2024: Enhancing Drug Safety and ADME Assessment with Organoids"
image: https://resources.huborganoids.nl/hubfs/social-media-sot-2024-poster.jpg
---

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PRESENTED AT SOT 2024

# Enhancing Drug Safety and ADME Assessment with Organoids

![SOT 2024 Poster](https://resources.huborganoids.nl/hs-fs/hubfs/assets2023/sot-poster-2024.png?width=400&name=sot-poster-2024.png)

Selecting suitable *in vivo* preclinical drug development models for absorption, distribution, metabolism, excretion (ADME) and toxicology studies poses chall enges due to inter-species variability, limited human relevance, and cost constraints. The FDA Modernization Act 2.0 has endorsed alternative *in vitro* models, with organoids emerging as valuable tools. Adult stem cell-derived HUB Organoids® from human and preclinical animal tissues have been shown to mimic tissue physiology accurately, offer high-throughput screening, and serve as a robust platform to predict drug toxicity, metabolism, and adverse effects in the intestine.

#### Download this poster to discover:

- Our innovative ADME and toxicology platform utilizing organoids derived from adult stem cells sourced from both human and animal species, including mini-pig, rat, and dog.
- The practical application of our platform in assessing preclinical gastrointestinal safety.
- Dive into two compelling case studies showcasing the platform's effectiveness in predicting toxicological outcomes.

### Download our poster

![Logo HUB Organoids](https://resources.huborganoids.nl/hubfs/raw_assets/public/HUBOrganoids_May2021/images/logo-huborganoids-white.svg "Logo HUB Organoids")

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HUB Organoids is now part of the Life Science Business of Merck KGaA, Darmstadt, Germany

***FOR RESEARCH USE ONLY.**  Unless otherwise stated in our catalog or other company documentation  
 accompanying the product(s), our products are intended for research use only and are not to be used   
 for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro   
 diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to   
humans or animals.*